Amorphous magnesium-substituted calcium phosphate compositions and their uses
AssigneeMedical Research Council
InventorsJonathan Joseph Powell, Nuno Jorge Rodriguez Faria, Laetitia Pele, Rachel Hewitt, Emma Thomas-McKay
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Abstract
Amorphous magnesium-substituted calcium, phosphate compositions and their medical uses are described, in particular for use in delivering cargo materials, such as cargo molecules or cargo nanoparticles contained in pores of the amorphous magnesium-substituted calcium phosphate to cells of the immune system, for example as therapeutic approaches for the treatment of inflammatory bowel diseases, and in particular Crohn's disease, autoimmune diseases, allergy and for therapeutic vaccination.
Claims40
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A method of treating or preventing a condition by delivering a biologically active cargo material to the gastrointestinal tract, the method comprising administering to a subject in need of treatment a composition comprising amorphous magnesium-substituted calcium phosphate (AMCP) which entraps the biologically active cargo material, thereby enabling the cargo material to be delivered to a site of interest in the gastrointestinal tract.
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A method of diagnosis or imaging, wherein the method comprises administering an amorphous magnesium-substituted calcium phosphate (AMCP), wherein the amorphous magnesium-substituted calcium phosphate entraps a detectable moiety.
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A process for producing amorphous magnesium-substituted calcium phosphate compositions that contain entrapped biologically active cargo material, the process comprising:
- (a) providing a solution comprising calcium ions (Ca2+), magnesium ions (Mg2+) and a solution comprising phosphate ions (PO42−), wherein one or both of the solutions comprise one or more biologically active cargo materials;
- (b) mixing the solution comprising calcium ions (Ca2+), magnesium ions (Mg2+) with the solution comprising phosphate ions (PO42−) to precipitate amorphous magnesium-substituted calcium phosphate in which the biologically active cargo material is entrapped;
- (c) recovering the amorphous magnesium-substituted calcium phosphate;
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- (d) optionally washing and drying the amorphous magnesium-substituted calcium phosphate.
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Dependencies are inferred from the claim text.