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AssigneeDow Global Technologies LLC
InventorsMeinolf Brackhagen, Matthias Knarr, Roland Adden
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A liquid composition which comprises an organic liquid diluent and a hydroxyalkyl methylcellulose which has a certain distribution of substituted hydroxyalkoxyl groups and unsubstituted hydroxyalkoxyl groups is stable over an extended time period. In the hydroxyalkyl methylcellulose hydroxyalkoxyl groups are classified into a fraction (A) and a fraction (B), wherein fraction (A) represents the sum of all molar fractions of substituted hydroxyalkoxyl groups having hydroxyl groups substituted further with methoxyl groups and fraction (B) represents the sum of all molar fractions of unsubstituted hydroxyalkoxyl groups having hydroxyl groups not substituted further with methoxyl groups and wherein the ratio fraction (A)/fraction (B) is at least 0.30. The liquid composition is useful for preparing a solid dispersion comprising at least one active ingredient in at least one hydroxypropyl methylcellulose by spray-drying.
A liquid composition comprising an organic liquid diluent, one or more active ingredients, and at least one hydroxyalkyl methylcellulose wherein hydroxyalkoxyl groups are classified into a fraction (A) and a fraction (B), wherein fraction (A) represents the sum of all molar fractions of substituted hydroxyalkoxyl groups having hydroxyl groups substituted further with methoxyl groups and fraction (B) represents the sum of all molar fractions of unsubstituted hydroxyalkoxyl groups having hydroxyl groups not substituted further with methoxyl groups and wherein the ratio fraction (A)/fraction (B) is at least 0.30.
The liquid composition of 1 wherein the organic liquid diluent is an alcohol, ether, ketone, acetate or halogenated hydrocarbon.
The liquid composition of 1 wherein the viscosity of the liquid composition, measured after 18 hours storage at 25° C., is not more than the 10-fold viscosity of the liquid composition at 25° C. that is measured 60 minutes after the liquid composition has been prepared, when the liquid composition comprises 10 weight percent of the hydroxyalkyl methylcellulose, based on the total weight of the liquid composition.
(canceled)
A solid dispersion comprising at least one active ingredient in at least one hydroxyalkyl methylcellulose wherein hydroxyalkoxyl groups are classified into a fraction (A) and a fraction (B), wherein fraction (A) represents the sum of all molar fractions of substituted hydroxyalkoxyl groups having hydroxyl groups substituted further with methoxyl groups and fraction (B) represents the sum of all molar fractions of unsubstituted hydroxyalkoxyl groups having hydroxyl groups not substituted further with methoxyl groups and wherein the ratio fraction (A)/fraction (B) is at least 0.30.
Dependencies are inferred from the claim text.