Method of converting a crystalline compound to an amorphous compound, method of increasing the solubility of a crystalline compound in a biorelevant fluid, and nanoparticles that achieve supersaturation

A particulate comprising:

• amorphous nanoparticles comprising
• an amorphous compound, and
• an amorphous polymer,
• the nanoparticles having been formed by electrospraying a solution from an electrospray device, the solution comprising the polymer and solvent and having been derived from the compound in its crystalline form.

A method of increasing the solubility of a poorly water soluble crystalline compound in a biorelevant fluid having a pH of at least 6.5, the method comprising:

• dissolving the compound and a polymer in a solvent to form a solution, the polymer being present in the solution in an amount such that, after electrospraying the solution, the compound is in an amorphous form;
• electrospraying the solution using an electrospray device, the electrospraying forming nanoparticles;
• collecting the nanoparticles on a substrate, and
• removing the nanoparticles from the substrate in the form of a dry powder, the nanoparticles comprising the compound in an amorphous form.