Reconstituted high density lipoproteins composition and uses thereof
AssigneeUniversité Pierre Et Marie Curie - Paris 6 (Upmc)
InventorsAnatol KONTUSH, John CHAPMAN, Marie LHOMME
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Abstract
A reconstituted high density lipoprotein composition including negatively charged phospholipids enhances cholesterol clearance, reduces inflammation and other anti-atherosclerotic actions.
Claims18
1-12. (canceled)
A reconstituted high density lipoprotein composition comprising apolipoprotein, fragments or combinations thereof and at least one negatively charged phospholipid, fragments or combinations thereof.
A method for treating a disorder related to the dysfunction of HDL metabolism comprising administering in a subject in need thereof an effective amount of a composition comprising reconstituted high density lipoprotein apolipoprotein, fragments or combinations thereof and at least one negatively charged phospholipid, fragments or combinations thereof.
A method for reducing atherosclerotic lesions in a subject in need thereof, comprising administering to the subject an effective amount of a composition comprising reconstituted high density lipoprotein apolipoprotein, fragments or combinations thereof and at least one negatively charged phospholipid, fragments or combinations thereof.
Dependencies are inferred from the claim text.