Liposomal pharmaceutical preparation and method for manufacturing the same
AssigneeCspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.
InventorsChunlei LI, Jinxu WANG, Caixia WANG, Yanhui LI, Dongmin SHEN, Wenmin GUO, Li ZHANG, Lan ZHANG
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Abstract
The present invention relates to a liposomal pharmaceutical preparation containing a multivalent ionic drug, a process for the preparation of the liposomal pharmaceutical preparation, and a use thereof in the treatment of diseases, in which the liposome has a size of about 30-80 nm, and the phospholipid bilayer has a phospholipid with a Tm higher than body temperature, so that the phase transition temperature of the liposome is higher than the body temperature.
Claims15
-19. (canceled)
A liposomal preparation comprising a multiplevalent ionic active compound in a liposome, wherein the liposome has a mean size of 30-80 nm, and the bilayer of the liposome comprises a phospholipid with a phase transition temperature (Tm) higher than body temperature, cholesterol, and a hydrophilic polymer-modified lipid;
- and the intraliposomal phase of the liposome comprises a multivalent counter ion.
A method of improving therapeutic index of a multiplevalent ionic active compound in a patient by releasing a liposome comprising the active compound in a target tissue effectively,
- wherein the liposome has a mean size of 30-80 nm;
- the bilayer of the liposome comprises a phospholipid with a phase transition temperature (Tm) higher than the body temperature, cholesterol, and a hydrophilic polymer-modified lipid;
- and the intraliposomal phase of the liposome comprises a multivalent counter ion;
- and
- wherein the method comprises administering the liposome to the patient.
Dependencies are inferred from the claim text.