Method and apparatus for making compositions for pulmonary administration
AssigneeVectura Limited
InventorMATTHEW GREEN
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Abstract
A method is disclosed for making a pharmaceutical composition for pulmonary administration comprising a pharmaceutically active protein or nucleic acid particle, the method comprising a step in which the inhalable pharmaceutically active protein or nucleic acid particle is acoustically blended in a resonant acoustic blender. The invention also relates to compositions for inhalation prepared by the method.
Claims21
A method for making a pharmaceutical composition for pulmonary administration comprising acoustically blending inhalable particles comprising a pharmaceutically active protein in a resonant acoustic blender, wherein the pharmaceutically active protein is not any one of palivizumab, interferon, Tumour Necrosis Factor Inhibitor, adamalysin, serralysin, astacin, aerugen and alpha 1-antitrypsin.
The method of claim wherein the non-reducing disaccharide has a D10≦250 μm, D50≦500 μm and D90≦800 μm.
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21-32. (canceled)
Dependencies are inferred from the claim text.