US 2016/0235346 A1 · Electrochemical Sensor for a Bandage Type of Continuous Glucose Monitoring System

Abstract

An electrochemical sensor of a flexible, body-mountable analyte sensing device is provided. The electrochemical sensor is disposed on a flexible sensor probe that is configured to penetrate the skin such that the electrochemical sensor disposed on the sensor probe can detect an analyte in interstitial fluid. The electrochemical sensor is made sensitive to the analyte by disposing a substance that selectively binds to reacts with, catalyzes a reaction of, or otherwise selectively interacts with the analyte. The substance is localized by crosslinking on the surface of an electrode and/or by being disposed in a polymer layer disposed on the electrode. The polymer layer can be a hydrogel. Further, a hydrogel layer can be formed on the sensor probe to protect elements of the sensor probe and to increase the biocompatibility of the sensor probe.

Claims20

Dependent claims

A sensor comprising:

a flexible substrate, wherein the flexible substrate is mountable to a skin surface, wherein the flexible substrate includes an elongate portion, wherein a distal end of the elongate portion is configured to extend beneath the skin surface to contact interstitial fluid;
and
a first electrode and a second electrode, wherein the first electrode and second electrode are disposed at the distal end of the elongate portion of the flexible substrate, wherein the first electrode is selectively sensitive to an analyte in the interstitial fluid, and wherein the first electrode and second electrode are configured to detect the analyte electrochemically.

A method comprising:

forming a first electrode and a second electrode on a flexible substrate, wherein the first electrode is selectively sensitive to an analyte in an interstitial fluid, wherein the first electrode and second electrode are configured to detect the analyte electrochemically;
and
trimming the flexible substrate to form a first trimmed flexible substrate that includes an elongate portion, wherein a distal end of the elongate portion is configured to extend beneath a skin surface to contact interstitial fluid, wherein the first trimmed flexible substrate is mountable to the skin surface, and wherein trimming the flexible substrate to form the first trimmed flexible substrate comprises trimming the flexible substrate such that the first electrode and second electrode are located at the distal end of the elongate portion of the first trimmed flexible substrate.

Dependencies are inferred from the claim text.

Facts

Application

15/043,817Filed 15 Feb 2016

Priority

16 Feb 2015

Published

18 Aug 2016

Term ends

Not estimatedThe source records don’t support an estimate.

Classification16 codes

A61B 5/1473
Using chemical or electrochemical methods, e.g. by polarographic means: invasive, e.g. introduced into the body by a catheter
A61B 5/14532
Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g.…: for…
A61B 5/14865
Using enzyme electrodes, e.g. with immobilised oxidase: invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
A61B 5/6847
Specially adapted to be brought in contact with an internal body part, i.e. invasive: mounted on an invasive device

Electrochemical Sensor for a Bandage Type of Continuous Glucose Monitoring System

Life of this patent

Electrochemical Sensor for a Bandage Type of Continuous Glucose Monitoring System

Life of this patent

Abstract

Claims20