System and method for myocardial perfusion pathology characterization

A method of characterizing myocardial perfusion pathology by analyzing a plurality of medical images of at least a portion of the heart of a subject of interest, the plurality of medical images being acquired in a consecutive manner by a medical imaging modality, the method comprising steps of:

• delineating contours of a selected part of the heart of the subject of interest in the plurality of medical images and segmenting the selected part into a plurality of segments;
• sampling intensities of selected myocardial image positions from the plurality of medical images and assigning an index representing an order of acquisition of each one of the medical images to the respective sampled intensities of the myocardial image positions to obtain intensity curves for each of the selected myocardial image positions;
• calculating an index number indicative of a spatio-temporal perfusion inhomogeneity or perfusion dephasing among at least a subset of myocardial segments of the plurality of myocardial segments, wherein the subset of myocardial segments includes a plurality of myocardial segments, based on the obtained intensity curves.