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US 2016/0229794 A1Published application
Photoreactive synthetic regulator of protein function and methods of use thereof
AssigneeThe Regents of the University of California
InventorsDirk Trauner, Ehud Y. Isacoff, Richard H. Kramer, Matthew R. Banghart, Doris L. Fortin, Alexandre Mourot
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Abstract
The present disclosure provides a photoreactive synthetic regulator of protein function. The present disclosure further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present disclosure further provides methods of modulating protein function, involving use of light.
Claims74
A synthetic regulator of polypeptide function, the regulator having the formula:
- (A)n-X1-(B)m-X2-(C)p, wherein
- A is a polypeptide association moiety;
- B is a photoisomerizable group;
- C is a ligand;
- each of n, m, and p is independently an integer from 1 to 10;
- X1, when present, is a spacer;
- and
- X2, when present, is a spacer.
5 more elements
Dependencies are inferred from the claim text.