US 2016/0228992 A1 · BONE REPLACEMENT MATERIALS

Abstract

Particular aspects provide novel devices for bone tissue engineering, comprising a metal or metal-based composite member/material comprising an interior macroporous structure in which porosity may vary from 0-90% (v), the member comprising a surface region having a surface pore size, porosity, and composition designed to encourage cell growth and adhesion thereon, to provide a device suitable for bone tissue engineering in a recipient subject. In certain aspects, the device further comprises a gradient of pore size, porosity, and material composition extending from the surface region throughout the interior of the device, wherein the gradient transition is continuous, discontinuous or seamless and the growth of cells extending from the surface region inward is promoted.

Claims20

Dependent claims

A method of producing a porous metal or metal-based composite device, comprising:

obtaining input data from bone imaging scans of a patient;
selecting at least one of a density, a modulus of elasticity or a compression strength of a device for bone tissue engineering based on the obtained input data from the bone imaging scans of the patient;
and
forming the device for bone tissue engineering to have the selected at least one of the density, the modulus of elasticity or the compression strength, wherein the device for bone tissue engineering includes a member of a biocompatible metal or metal-based composite, the member having an exterior surface, an interior voided core area, and a porous exterior surface region, and wherein an increasing porosity vol % gradient extends from the exterior surface, through the porous exterior surface region, and throughout the interior voided core area.

1 more element

Dependencies are inferred from the claim text.

Bone replacement materials

Life of this patent

Bone replacement materials

Life of this patent

Abstract

Claims20