Solid Forms of Ceftolozane
AssigneeMerck Sharp & Dohme Corp.
InventorsYou Seok Hwang, Nicole Miller Damour, Lisa Duong, Valdas Jurkauskas, Kristos Adrian Moshos, Sanjay Mudur, Asli Ovat, Joseph Terracciano, Jason Woertink
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Abstract
Ceftolozane Sulfate is a cephalosporin antibacterial agent. Novel, stable, solid forms of the pharmaceutically acceptable sulfate salt of ceftolozane have been isolated via lyophilization. Characterization and identification of these solid forms by XRPD and Raman IR, as well as methods for their preparation and use in pharmaceutical compositions, are described.
Claims29
A solid form of ceftolozane sulfate that produces an X-ray powder diffraction (XRPD) pattern having diffractions at angles (2 theta±0.2) of 12.4, 16.4, 22.6, 25.1, and 28.0.
A solid form of ceftolozane sulfate that produces:
- a. an X-ray powder diffraction (XRPD) pattern having diffractions at angles (2 theta±0.2) of 24.2 and 37.8 and
- b. Raman shift peaks (±5 cm−1) at about 597 cm−1, 716 cm−1 and 1329 cm−1.
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A solid form of ceftolozane sulfate that produces an X-ray powder diffraction (XRPD) pattern having diffractions at angles (2 theta±0.2) of 4.4, 8.8, 11.0, 14.9, and 17.7.
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Dependencies are inferred from the claim text.