US 2016/0222212 A1 · Asulfonate Discrete PEG Based Dyes

Abstract

Disclosed are discrete PEGylated dyes, that is, dyes, generally ones that are fluorescent, but could also include chemiluminescent or electrochemiluminescent and related dye or dye precursors, that have discrete PEG constructs chemically attached in various configurations on the dye, and in the entire range of constructs, discrete PEG compounds (polyethylene glycol oligomers that are made synthetically according to methods disclosed in U.S. Pat. No. 7,888,536 and US Pub. No. 2013/0052130). The dyes are modified in a range of ways to control or optimize the properties of water solubility, non-specific binding (in vitro), biodistribution (in vivo), cell internalization (non-cell or cell based assays in vitro, and in vivo diagnostics and therapy), as well as aggregation. The modified dyes do not contain sulfonate groups and, thus, are asulfonate modified dyes.

Claims8

Dependent claims

Asulfonate modified dyes comprising a dye substituted with:

where:
(a) (A) is a reactive or reactable group;
(b) the solid line, , is one or more linear discrete PEG-containing chain having between about 0 and 64 ethylene oxide residues and having a terminal moiety that is not an ethylene oxide residue;
and
(c) the wavy line, is a linear discrete PEG containing chain optionally substituted with one or more of N, S, Si, Se, or P and terminated with a reactive or a reactable group (A).

2 more elements

Dependencies are inferred from the claim text.

Asulfonate Discrete PEG Based Dyes

Life of this patent

Asulfonate Discrete PEG Based Dyes

Life of this patent

Abstract

Claims8