Recombinant marek's disease viruses and uses thereof
AssigneeCeva Sante Animale
InventorsMotoyuki Esaki, Shuji Saitoh, Takanori Sato
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Abstract
The present invention relates recombinant viruses and the uses thereof. More particularly, the invention relates to novel recombinant Marek's disease viruses encoding polypeptide(s) of interest, and their use to express or deliver such polypeptides to animals, particularly poultry. The invention is particularly suited to vaccinate poultry against avian pathogens.
Claims24
A recombinant Marek's disease virus of serotype 1 (MDV1) which comprises (1) a promoter consisting of a chicken beta-actin derived promoter and (2) under the control of said promoter, a recombinant nucleotide sequence encoding a polypeptide.
A recombinant nucleic acid molecule comprising the genome of a MDV1 or a fragment thereof, wherein said genome or fragment comprises a US2 gene modified by insertion of a recombinant nucleotide sequence comprising a sequence encoding a polypeptide under the control of a promoter comprising a core sequence of a chicken beta-actin promoter.
Dependencies are inferred from the claim text.