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US 2016/0220650 A1Published application
Cytomegalovirus-based immunogenic preparations
AssigneeOregon Health & Science University
InventorsAnn B. Hill, Christopher M. Snyder
Life of this patent
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Abstract
Methods of using recombinant replication-deficient cytomegalovirus (CMV) to generate a long-term, repeatedly stimulated immune response in a subject, for instance against a heterologous antigen expressed by the cytomegalovirus, are described. Also described are methods of using a recombinant replication deficient CMV as an anti-cancer immunogenic preparation.
Claims17
A method of generating a long term, repeatedly stimulated immune response against a cancer antigen in a subject, the method comprising:
- administering to the subject, by intraperitoneal or intravenous administration, a recombinant, replication-deficient cytomegalovirus comprising a nucleic acid encoding the cancer antigen, thereby generating the long term, repeatedly stimulated immune response against the cancer antigen.
Dependencies are inferred from the claim text.