Peptoid oligomers, pharmaceutical compositions and methods of using the same
AssigneeNew York University
InventorsKent Kirshenbaum, Sung Bin Shin
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Abstract
Novel peptoid oligomers are disclosed that have a formula represented by the following formula I: The peptoids demonstrate antimicrobial activity and may be prepared as pharmaceutical compositions and used for the prevention or treatment of a variety of conditions in mammals including humans where microbial invasion is involved. The present cyclic and linear peptoids are particularly valuable as their effect is rapid, broad in spectrum and mostly indifferent to resistance provoked by standard antibiotics.
Claims15
1-66. (canceled)
A method for preventing, treating, ameliorating or managing a disease or condition, which comprises administering to a patient in need of such prevention, treatment, amelioration or management a therapeutically acceptable amount of a peptoid oligomer according to formula Ia
- or a salt thereof;
- and stereoisomers, isotopic variants and tautomers thereof;
- wherein the said peptoid oligomer consists of one or more monomers selected from Nap, Nab, Nah, Ngb, Npm, Nnm, Ndp, Nip, Nib and Pro:
- X is H, or substituted or unsubstituted acyl;
- Y is NH2, OH, acylamino, or acyloxy;
- and
- n is an integer between 2-20.
A method for preventing, treating, ameliorating or managing a disease or condition, which comprises administering to a patient in need of such prevention, treatment, amelioration or management a therapeutically acceptable amount of a peptoid oligomer according to formula Ib
- or a salt thereof;
- and stereoisomers, isotopic variants and tautomers thereof;
- wherein the said peptoid oligomer consists of one or more monomers selected from Nap, Nab, Nah, Ngb, Npm, Nnm, Ndp, Nip, Nib and Pro:
- and
- n is an integer between 4-20.
A peptoid oligomer according to formula Ib
- or a salt thereof;
- and stereoisomers, isotopic variants and tautomers thereof;
- wherein the said peptoid oligomer consists of one or more monomers selected from Nap, Nab, Nah, Ngb, Npm, Nnm, Ndp, Nip, Nib and Pro:
- n is an integer between 4-20;
- and at least one of the monomers in the peptoid oligomer is Nap, Nab, Nah, or Ngb.
Dependencies are inferred from the claim text.