Magnetic nano core-shell capsule and application thereof

A magnetic nano core-shell capsule for drug delivery, comprising:

• a plurality of amphiliphilic proteins, wherein the amphiliphilic protein has a hydrophilic end and a hydrophobic end;
• a plurality of iron oxide (Fe3O4) nanoparticles;
• a hydrophilic drug;
• and
• a hydrophobic drug,
• wherein the hydrophilic ends of the amphiliphilic proteins form a first space, the hydrophobic ends of the amphiliphilic proteins surround the hydrophobic end of the amphiliphilic proteins to form a second space, the second space surrounds the first space, and the hydrophilic drug is in the first space, and iron oxide nanoparticles and the hydrophobic drug are in the second space;
• wherein the first space forms an aqueous phase core layer, the second space forms an oil phase shell layer, and the hydrophilic drug is in the aqueous phase core layer, the hydrophobic drug is in the oil phase shell layer;
• and
• wherein the ratio of the amphiliphilic proteins and the iron oxide nanoparticles is 1:0.8 to 1:16.7.