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US 2016/0177248 A1Published application
Pivoting pressurized single use bioreactor
AssigneeTherapeutic Proteins International, LLC
InventorSarfaraz K. Niazi
Life of this patent
Estimating the term…
Abstract
Pressurized hermetically sealed bags disposed inside a cylindrical support and containing a septum with variable density of porosity and dividing the bag into two chambers are used to provide optimal mixing and gasification of nutrient media to grow a variety of biological cultures, particularly the cell cultures to produce a multitude of pharmaceutical and biotechnology products in a disposable system.
Claims10
A mixing device comprising:
- a) a cylindrical support with an inner surface configured to immovably retain a single-use flexible container;
- b) a single-use flexible container capable of containing a liquid comprising:
- i) A flexible septum with an inner surface immovably positioned within the flexible container and defining a right chamber and a left chamber, the septum comprising a plurality of pores with a variable density over the surface of the septum;
- ii) At least one liquid inlet;
- iii) At least one liquid outlet;
- iv) At least one gas inlet in fluid communication with a source of compressed gas;
- v) At least one gas outlet capable of controlling the rate of flow of gas;
- vi) at least one sensor to measure the temperature of a liquid in the flexible container;
- and
- vii) A heater and/or a cooling element for controlling the temperature of the flexible container;
- c) a shaft for pivoting the cylindrical support along its circular axis between −110 to +110 degrees;
- and wherein, the flexible container is immovably fixed to the inner surface of the cylindrical support.
9 more elements
Dependencies are inferred from the claim text.