Transducible materials for cell reprogramming
AssigneeVivoscript, Inc.
InventorsYong ZHU, Huei-Sheng Vincent CHEN, Shili WU, Jun BAO
Life of this patent
Estimating the term…
Abstract
The present inventions are directed to compositions and methods regarding the reprogramming of biological samples (such as cells) without introducing exogenous genes to the sample. In particular, the present inventions are directed to transducible materials that are capable of transducing into the nuclei and have enhanced retention in the nuclei of the biological sample. The present inventions also are directed to methods of reprogramming a biological sample or treating diseases using the transducible compositions thereof.
Claims26
A transducible material comprising an isolated polypeptide capable of transducing and retaining in a cell nucleus, said isolated polypeptide comprising an effector domain, wherein the effector domain comprises an amino acid sequence mutated from a nuclear export signal (NES).
(canceled)
26-30. (canceled)
Dependencies are inferred from the claim text.