Bi-specific adapters
OwnerHelene Verheije, Paul van Bergen en Henegouwen +2inventors
InventorsHelene Verheije, Paul van Bergen en Henegouwen, Peter Rottier, Marta Kijanka
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Abstract
The present invention relates to bi-specific adapters for re-directing viruses to non-virus specific host cells, to expression cassettes comprising a DNA molecule having a nucleotide sequence encoding such bi-specific adapters, to recombinant Coronaviruses comprising such expression cassettes and to their use as a medicament and their use in the treatment of tumors.
Claims21
1-8. (canceled)
A recombinant Coronavirus comprising an expression cassette that comprises an RNA or DNA molecule comprising a nucleotide sequence encoding a bi-specific adapter;
- wherein said bi-specific adapter is a protein that comprises a Coronavirus Spike-protein receptor moiety and a camelid VHH antibody moiety;
- and
- wherein said nucleotide sequence is under the control of a transcription regulatory sequence (TRS).
Dependencies are inferred from the claim text.