Backflush methods and devices for chromatography
AssigneePerkinElmer Health Sciences, Inc.
InventorAndrew Tipler
Life of this patent
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Abstract
Certain embodiments described herein are directed to chromatography systems that include a microfluidic device and that implement one or more methods to direct sample to a desired fluid flow path. The methods can be used to backflush a sample to a desired fluid flow path to select certain analytes within a sample.
Claims16
1-24. (canceled)
A kit comprising:
- a microfluidic device comprising a laminated wafer body comprising an input port, a first outlet port and a second outlet port, in which each of the first outlet port and the second outlet port is fluidically coupled to the inlet port through an internal microchannel within the microfluidic device, the microfluidic device configured to provide a sample from the input port to the first outlet port when the microfluidic device is in a first state, to provide the sample from the input port to the second outlet port when the microfluidic device is in a second state and to reverse flow of the sample in the microchannel when the microfluidic device in a third state;
- and
- instructions for using the microfluidic device to backflush the sample.
A kit comprising:
- a microfluidic device comprising a laminated wafer body comprising an input port, a first outlet port and a second outlet port, in which each of the first outlet port and the second outlet port is fluidically coupled to the inlet port through an internal microchannel within the microfluidic device, the microfluidic device configured to provide a sample from the input port to the first outlet port when the microfluidic device is in a first state, to provide the sample from the input port to the second outlet port when the microfluidic device is in a second state and to reverse flow of the sample in the microchannel when the microfluidic device in a third state;
- and
- at least one ferrule configured to provide fluidic coupling between a fluid flow path outside of the microfluidic device and at least one of the input port, the first outlet port and the second outlet port of the microfluidic device.
A system comprising a microfluidic device comprising a laminated wafer body comprising an input port, a first outlet port and a second outlet port, in which each of the first outlet port and the second outlet port is fluidically coupled to the inlet port through an internal microchannel within the microfluidic device, the microfluidic device configured to provide a sample from the input port to the first outlet port when the microfluidic device is in a first state, to provide a sample from the input port to the second outlet port when the microfluidic device is in a second state and to reverse flow of the sample in the microchannel when the microfluidic device in a third state.
Dependencies are inferred from the claim text.