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US 2016/0159929 A1Published application
Novel dual-targeting protein binding specifically to dll4 and vegf and use thereof
AssigneeAblbio
InventorsDong Heon Lee, Kyung Duk Moon, Yu Bin Choi, Kyung Jae Kang, Dong In Kim, Jin Hyung Ahn, Weon Kyoo You, Jinwon Jung
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Abstract
The present invention relates to a novel dual-targeting protein comprising: a protein that binds specifically to delta-like ligand 4 (DLL4); and an antibody that binds specifically to vascular endothelial cell growth factor (VEGF).
Claims24
A dual-targeting protein comprising:
- a protein specifically binding to DLL4, which recognizes a conformational epitope of DLL4 comprising amino acid residues 58th to 65th amino acid sequences and 110th to 115th amino acid sequences in amino acid sequences of DLL4 protein represented by SEQ ID NO:21, and an antibody specifically binding to VEGF (Vascular endothelial growth factor).
-19. (canceled)
A conformational epitope of DLL4 comprising amino acid residues 58th to 65th and 110th to 115th in the amino acid sequence of a DLL4 (delta-like ligand 4) protein represented by SEQ ID NO:
- 21.
Dependencies are inferred from the claim text.