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US 2016/0159834 A1Published application
Alkyne phosphoramidites and preparation of spherical nucleic acid constructs
AssigneeNorthwestern University
InventorsAndrew Lee, Chad A. Mirkin, Colin Michael Calabrese, Natalia Chernyak, Evelyn Auyeung
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Abstract
The present disclosure is directed to compositions comprising alkyne oligonucleotides, nanoconjugates prepared from the same, and methods of their use.
Claims33
A compound having a structure of formula (I) or (II):
- wherein
- R1 is an alcohol protecting group;
- each R2 is a C1-10alkyl;
- each R3 is a C10-30alkyl;
- and
- L1 is a hydrophilic linker comprising 2-10 ethyleneoxy units.
3 more elements
(canceled)
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(canceled)
A compound having a structure of formula (III):
- wherein
- R1 is an alcohol protecting group;
- each R2 is a C1-10alkyl;
- and
- R4 is a C3-10alkyl.
2 more elements
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.