Compositions and Methods of Altering Cholesterol Levels
AssigneeModerna Therapeutics, Inc.
InventorsStephen G. HOGE, Eric Yi-Chun HUANG, Joseph Beene BOLEN, Justin GUILD, Antonin DE FOUGEROLLES, Jeff Lynn ELLSWORTH
Life of this patent
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Abstract
The present invention relates to compositions, methods and kits using polynucleotides, primary transcripts and mmRNA molecules. The present invention also relates to compositions and methods for altering cholesterol levels using polynucleotides, primary transcripts and mmRNA molecules.
Claims28
A composition comprising;
- (a) a first polynucleotide encoding a LDLR mutant having one or more amino acids substituted such that the LDLR mutant is deficient in PCSK9 binding, and
- (b) a second polynucleotide encoding a CYP7A1 protein, and
- (c) an excipient.
2-6. (canceled)
8-10. (canceled)
14-17. (canceled)
(canceled)
A polynucleotide comprising an mRNA encoding a LDLR mutant having one or more amino acids substituted such that the LDLR mutant is deficient in PCSK9 binding, wherein the one or more amino acids correspond to amino acid 316 of SEQ ID NO:
- 19, amino acid 317 of SEQ ID NO:19, amino acid 331 of SEQ ID NO:19, amino acid 336 of SEQ ID NO:19, amino acid 339 of SEQ ID NO:19, or any combination thereof.
Dependencies are inferred from the claim text.