Bacteriophage-polymer hybrid
AssigneeImperial Innovations Limited
InventorsAmin Hajitou, Teerapong Yata
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Abstract
The invention provides a targeted bacteriophage-polymer complex comprising a recombinant targeted-bacteriophage and a cationic polymer. The complex has a net positive charge. The invention provides methods of preparing bacteriophages and complexes thereof, and to their uses for the delivery of transgenes in a variety of gene therapy applications.
Claims34
A targeted bacteriophage-polymer complex comprising a recombinant targeted-bacteriophage and a cationic polymer, wherein the complex has a net positive charge.
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A method of producing a targeted bacteriophage-polymer complex, the method comprising contacting a recombinant targeted-bacteriophage with a cationic polymer to form a stable complex, which has a net positive charge.
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A method of treating, preventing or ameliorating a disease in a subject using a gene therapy technique, the method comprising administering, to a subject in need of such treatment, a therapeutically effective amount of the targeted bacteriophage-polymer complex according to the first aspect or the aggregate according to the third aspect.
Dependencies are inferred from the claim text.