Methods for Safe Administration of Nephrotoxic Agents

A method for treating inflammation, infection or a neoplastic disease in a human being, said method comprising

• i) administering an effective amount of an anti-inflammatory, anti-infectious or anti-neoplastic agent to said human being, wherein said agent is nephrotoxic,
• ii) determining the concentration of human neutrophil gelatinase associated lipocalin (NGAL) by using an antibody that binds specifically to NGAL in a sample of plasma or urine from said adult human being, and
• iii) comparing said concentration with a cutoff value, said cutoff value being from 200 ng/mL to 100 ng/mL NGAL, wherein concentrations below said cutoff values indicate that said human being is not at risk of having or developing acute renal failure, and
• iv) continuing said administration of said agent when said concentration of NGAL in said sample equals or is below the cutoff value.