Methods And Compositions For Determining Fortilin Levels
AssigneeBoard of Regents, The University of Texas System
InventorKen Fujise
Life of this patent
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Abstract
Certain embodiments are directed to method of measuring fortilin in a serum sample as a biomarker of in vivo apoptosis, which can be utilized to noninvasively assess the status of in vivo apoptosis in a subject.
Claims8
A method of measuring fortilin in a blood sample comprising contacting a blood sample with an antibody that specifically binds fortilin forming an antibody/fortilin complex;
- contacting the antibody/fortilin complex with a detection reagent;
- and measuring the amount of detection reagent bound to the antibody/fortilin complex.
A method for determining the level of in vivo apoptosis in a subject comprising measuring fortilin levels in a blood sample from the subject and determining whether the fortilin levels exceed a predetermined threshold representing levels of fortilin in a subject not having a disease, condition, or undergoing a therapy, wherein elevated fortilin levels are indicative of increased apoptosis associated with the disease, condition, or therapy.
Dependencies are inferred from the claim text.