Methods for diagnosing and treating bicuspid aortic valve and/or aortopathies
AssigneeThe Trustees of the University of Pennsylvania
InventorsGiovanni FERRARI, Emanuela BRANCHETTI
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Abstract
Provided herein are methods for identifying and treating BAV disease and/or aortopathy in a subject, and methods of improving outcome in a subject. The subject may be asymptomatic of BAV disease and/or aortopathy, experiencing symptoms of BAV disease and/or aortopathy, have BAV disease and/or aortopathy, or be a blood relative of an individual having BAV disease and/or aortopathy. Levels of sRAGE in the subject's biological sample are determined, compared to a control biological sample, and used as an indicator for the presence and severity of BAV disease and/or aortopathies, a tool to screen family members, and an indicator of the proper surgical or treatment regimens.
Claims28
A method of treating BAV disease and/or aortopathy in a subject comprising:
- determining the level of sRAGE in a biological sample of the subject,
- comparing the level of sRAGE in the subject's biological sample to the level of sRAGE in a control biological sample, wherein an increased level of sRAGE in the biological sample of the subject relative to the level of sRAGE in the control biological sample is indicative of the subject having BAV disease and/or aortopathies;
- and
- treating the subject for BAV disease and/or aortopathy if the level of sRAGE in the biological sample of the subject is increased relative to the level of sRAGE in the control biological sample.
A method for treating a subject who
- is asymptomatic of BAV disease and/or an aortopathy;
- is experiencing symptoms of BAV disease and/or an aortopathy;
- has BAV disease and/or an aortopathy;
- or
- is a blood relative of an individual having BAV disease and/or an aortopathy comprising
- determining the level of sRAGE in a biological sample from the subject;
- comparing the level of sRAGE in the subject's biological sample to the level of sRAGE in a control biological sample and
- treating said subject if the level of sRAGE in the biological sample of the subject is increased relative to the level of sRAGE in the control biological sample.
Dependencies are inferred from the claim text.