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US 2016/0109449 A1Published application
Antibodies or fragments thereof directed against a staphylococcus aureus epitope of isaa or isab
AssigneeJulius-Maximilians-Universitaet Wuerzburg
InventorsKnut Ohlsen, Udo Lorenz
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Abstract
The invention concerns antibodies or fragments thereof that are directed against a Staphylococcus aureus epitope.
Claims4
A method of detecting Staphylococcus aureus, comprising:
- contacting an isolated antibody or fragment thereof with a sample suspected of comprising Staphylococcus aureus, wherein said antibody or fragment thereof:
- (a) binds to an immunodominant Staphylococcus aureus antigen IsaA epitope and is secreted by the hybridoma cell line deposited at the DSMZ under accession number DSM ACC2987,
- (b) binds to an immunodominant Staphylococcus aureus antigen IsaA epitope selected from the group consisting of:
- SEQ ID NO:
- 15, 17 to 19, 21 to 26, 32 to 34 and 57,
- (c) binds to an immunodominant Staphylococcus aureus antigen IsaB epitope and is secreted by the hybridoma cell line deposited at the DSMZ under accession number DSM ACC2988, or
- (d) binds to an immunodominant Staphylococcus aureus antigen IsaB epitope and comprises a heavy chain variable region and a light chain variable region, wherein the sequence of the heavy chain variable region comprises SEQ ID NO:
- 6 and the sequence of the light chain variable region comprises SEQ ID NO:
- 8.
6 more elements
A kit, comprising:
- an isolated antibody or fragment thereof, wherein said antibody or fragment thereof:
- (a) binds to an immunodominant Staphylococcus aureus antigen IsaA epitope and is secreted by the hybridoma cell line deposited at the DSMZ under accession number DSM ACC2987,
- (b) binds to an immunodominant Staphylococcus aureus antigen IsaA epitope selected from the group consisting of:
- SEQ ID NO:
- 15, 17 to 19, 21 to 26, 32 to 34 and 57,
- (c) binds to an immunodominant Staphylococcus aureus antigen IsaB epitope and is secreted by the hybridoma cell line deposited at the DSMZ under accession number DSM ACC2988, or
- (d) binds to an immunodominant Staphylococcus aureus antigen IsaB epitope and comprises a heavy chain variable region and a light chain variable region, wherein the sequence of the heavy chain variable region comprises SEQ ID NO:
- 6 and the sequence of the light chain variable region comprises SEQ ID NO:
- 8.
6 more elements
Dependencies are inferred from the claim text.