Peptides and methods for the detection of lyme disease antibodies
AssigneeAbaxis, Inc.
InventorsRajesh K. MEHRA, Kenneth P. ARON, Dennis M. BLEILE, Jeremy WALKER, Cristina CUESICO
Life of this patent
Estimating the term…
Abstract
The invention provides compositions (e.g., peptide compositions) useful for the detection of antibodies that bind to Borrelia antigens. The peptide compositions comprise polypeptide sequences comprising variants in the IR6 domain of the Borrelia VlsE protein. The invention also provides devices, methods, and kits comprising such peptide compositions and useful for the detection of antibodies that bind to Borrelia antigens and the diagnosis of Lyme disease.
Claims28
A mixture of isolated peptides comprising three or more different isolated peptides, wherein each isolated peptide comprises a sequence of L-K-K-D-D-N-I-A-A-A-X11-V-L-R-G-X16-X17-K-D-G-X21-F-A-X24-X25 (SEQ ID NO:
- 1) wherein X11 is an amino acid selected from the group consisting of V and L, X16 is an amino acid selected from the group consisting of L and I, X17 is an amino acid selected from the group consisting of A and V, X21 is an amino acid selected from the group consisting of R, D and N, X24 is an amino acid selected from the group consisting of I, W, and Y, and X25 is an amino acid selected from the group consisting of K and R.
-20. (canceled)
-24. (canceled)
(canceled)
Dependencies are inferred from the claim text.