Methods and compositions for the diagnosis of crohn's disease
AssigneesAlba Therapeutics Corporation, University of Maryland, Baltimore
InventorsJulio Bai, Alessio Fasano, Blake Paterson, Alicia Sambueli
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Abstract
The present invention provides methods and materials, including kits, to evaluate Crohn's disease, including to diagnose, monitor, or determine the efficacy of treatment for Crohn's Disease. The methods involve determining the presence, absence, or level of zonulin in a subject sample. In certain embodiments, the need for more laborious and/or invasive tests to monitor disease state is minimized or obviated.
Claims22
A method of evaluating Crohn's disease in a subject, comprising:
- obtaining a subject sample;
- and
- determining the level of zonulin in the sample, wherein an increased level of zonulin is predictive of active Crohn's disease.
A kit for diagnosing Crohn's disease, comprising:
- a means for binding zonulin;
- and
- a means for detecting zonulin.
A method of evaluating Crohn's disease in a subject diagnosed as having Crohn's disease, consisting essentially of:
- obtaining a subject sample;
- and
- determining the level of zonulin in the sample, wherein an increased level of zonulin is predictive of active Crohn's Disease or severity of Crohn's Disease.
Dependencies are inferred from the claim text.