Mechanical biomarkers for oocyte and embryo viability
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsLivia Zarnescu, David B. Camarillo, Jinnuo Han, Renee A. Reijo Pera, Shawn L. Chavez, Barry Behr
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Abstract
Provided are methods for the determination of the viability of a mammalian embryo or a potential embryo generated from a mammalian oocyte, comprising applying a mechanical stimulus to the embryo or oocyte, detecting a temporal response of the embryo or oocyte to the mechanical stimulus, and deriving measurements for one or more parameters from the temporal response, the measurements being indicative of viability. Also provided are methods for selecting an embryo for transfer and methods for enhancing the viability of an embryo or oocyte.
Claims3
1-20. (canceled)
A method for determination of a viability of a mammalian embryo or a potential embryo generated from a mammalian oocyte, comprising:
- performing aspiration on a portion of a surface of the embryo or oocyte to inflate the embryo or oocyte;
- detecting a temporal response of the embryo or oocyte to the aspiration using a microscope, the temporal response including aspiration depths of the embryo or oocyte as a function of time;
- and
- deriving measurements for one or more parameters from the temporal response, the measurements being indicative of viability.
Dependencies are inferred from the claim text.