Solid state nmr spectroscopy/imaging in situ measuring devices and methods for calibration and determining one or more quantitative properties of a target sample

A method for performing one or more quantitative measurements of a target sample using solid state MAS NMR spectroscopy, the method comprising:

• providing an in situ measuring device, the in situ measuring device comprising a solid state MAS NMR rotor and at least one sealed capillary tube positioned inside the solid state MAS NMR rotor, the at least one sealed capillary tube having a reference material sealed inside the at least one capillary tube, wherein a target sample is positioned on the inside of the solid state MAS NMR rotor;
• inserting the in situ measuring device inside a probe of a solid state MAS NMR instrument,
• while the in situ measuring device is positioned inside a probe of a solid state MAS NMR instrument, obtaining MAS NMR spectra of the target sample and the reference material, wherein at least one MAS NMR spectra peak associated with the reference material is spaced apart from at least one MAS NMR spectra peak associated with the target material;
• and
• determining one or more of a quantity of the target sample or a chemical identity of the target sample based on the MAS NMR spectra of the target sample and the reference material.

A method for forming an in situ measuring device for solid state MAS NMR spectroscopy, the method comprising:

• providing at least one capillary tube;
• adding at least one reference material to an inside cavity of the at least one capillary tube;
• sealing one or more ends of the at least one capillary tube to form at least one sealed capillary tube having the at least one reference material inside;
• providing a solid state MAS NMR rotor, the solid state MAS NMR rotor configured to house a target sample;
• and
• and positioning the at least one sealed capillary tube inside the solid state MAS NMR rotor.