In Situ NMR Parameter Monitoring Systems and Methods for Measuring PH and Temperature

A method for measuring a pH of a sample in situ using NMR spectroscopy, the method comprising:

• providing an in situ NMR pH measurement device, the device comprising:
• (1) a sample housing member configured to house a target sample,
• (2) at least one pH sensor configured to exhibit an NMR spectral change due to a change in pH value of the target sample, and
• (3) a pH sensor containment member configured to house the at least one pH sensor;
• adding the target sample to the sample housing member;
• obtaining one or more NMR spectra;
• and
• determining the pH of at least a portion of the target sample.

A device for monitoring a temperature of a sample in situ using NMR spectroscopy, the device comprising:

• an NMR sample tube;
• at least one capillary tube positioned inside the NMR sample tube, wherein the at least one capillary tube is configured to house a reference material;
• and
• a glass seal at a first end and at a second end of the at least one capillary tube that seals the first end and second end after the reference material has been added.

A method for measuring a temperature of a sample in situ using NMR spectroscopy, the method comprising:

• providing an in situ NMR temperature measurement device, the device comprising:
• (1) an NMR sample tube;
• (2) at least one capillary tube positioned inside the NMR sample tube, wherein the at least one capillary tube is configured to house a reference material and be sealed once the reference material has been added;
• adding the target sample to the NMR sample tube;
• obtaining one or more NMR spectra;
• and
• determining the temperature of at least a portion of the target sample based on at least one NMR spectrum of the reference material.

A method for forming a seal at one or both ends of a capillary tube used in an in situ NMR temperature measurement device, the method comprising:

• providing at least one capillary tube used in the in situ NMR temperature measurement device;
• adding a reference material to at least a portion of the at least one capillary tube;
• and
• using an Optical Fiber Arc Fusion Splicer to seal a first end of the at least one capillary tube.