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AssigneeMax-Planck-Gesellschaft Zur Foerderund Der Wissenschaften E.V.
InventorsMichal-Ruth SCHWEIGER, Christina GRIMM, Ralf HERWIG, Hans LEHRACH
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The invention relates to the identification and selection of novel genomic regions (biomarker) and the identification and selection of novel genomic region combinations which are hypermethylated in subjects with colorectal cancer compared to subjects without colorectal cancer. Nucleic acids which selectively hybridize to the genomic regions and products thereof are also encompassed within the scope of the invention as are compositions and kits containing said nucleic acids and nucleic acids for use in diagnosing prostate cancer. Further encompassed by the invention is the use of nucleic acids which selectively hybridize to one of the genomic regions or products thereof to monitor disease progression or regression in a patient and the efficacy of therapeutic regimens.
A method for diagnosis of colorectal cancer, comprising the steps of
The method according to claim 0, wherein the at least one genomic region is selected from the group of:
The method according to claim 0, wherein the at least one genomic region is genomic region number 1.
A chemically synthesized nucleic acid molecule that hybridizes under stringent conditions in the vicinity of one of the genomic regions according to genomic region number 1 to genomic region number 64, wherein said vicinity is any position having a distance of up to 500 nt from the 3′ or 5′ end of said genomic region, wherein said vicinity includes the genomic region itself.
Dependencies are inferred from the claim text.