Methods for production of l-methionine and related products
AssigneeCj Cheiljedang Corporation
InventorsSoon Won HONG, In Seok HWANG, Sang Mok LEE, Youn Jae LEE, Jun Young JUNG, Aharon Eyal
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Abstract
A method comprising: (a) enzymatically processing an O-acetylhomoserine (OAHS) fermentation liquor to produce L-methionine and an acetate source; (b) separating at least a portion of said L-methionine from at least a fraction of said acetate source to form separated L-methionine and a residual liquor comprising an acetate-source; and (c) recovering at least a portion of said acetate source from said residual liquor as recovered acetate.
Claims21
1-71. (canceled)
A method for producing an L-methionine product comprising;
- (a) providing a fermentation liquor comprising an L-methionine precursor selected from the group consisting of O-acetylhomoserine (OAHS) and O-succinyl homoserine (OSHS), and at least one impurity;
- (b) enzymatically processing said precursor to produce a reaction liquor comprising L-methionine, an organic acid selected from the group consisting of acetic acid and succinic acid and at least one impurity;
- (c) modifying said reaction liquor to form a crystallizing feed;
- (d) crystallizing L-methionine from said crystallizing feed to form crystalline L-methionine and an L-methionine-depleted mother liquor;
- and
- (e) recovering at least a portion of said organic acid from said mother liquor as recovered organic acid;
- wherein said recovering comprises producing a residual liquor containing said free organic acid and separating said free organic acid,
- and said crystalline L-methionine is characterized by at least one characteristic selected from the group consisting of:
- (i) purity greater than 95%;
- (ii) containing less than 1% organic acid;
- (iii) L-methionine precursor content greater than 1 PPB;
- (iv) content of at least one particular impurity is greater than 10 PPM;
- (v) less than 2% of D-methionine;
- and
- (vi) carbon-14 to carbon-12 ratio of at least 2.0×10−13.
A method for producing an L-methionine comprising;
- (a) enzymatically processing a fermentation liquor comprising an L-methionine precursor selected from the group consisting of O-acetylhomoserine (OAHS) and O-succinyl homoserine (OSHS) to produce L-methionine and a source of an organic acid selected from acetic acid and succinic acid;
- (b) separating at least a portion of said L-methionine from at least a fraction of said source of organic acid to form separated L-methionine and a residual liquor comprising the source of organic acid;
- and
- (c) recovering at least a portion of said source of organic acid from said residual liquor as recovered organic acid, wherein said recovering comprises producing said residual liquor containing free organic acid and separating said free organic acid.
Dependencies are inferred from the claim text.