Hydrophobically Modified Antisense Oligonucleotides Comprising a Ketal Group
AssigneesInstitut National De La Sante Et De La Recherche Medicale (Inserm), Universite De Bordeaux, Universite D'Aix-Marseille, Institut Jean Paoli & Irene Calmettes, Centre National De La Recherche Scientifique
InventorsPhilippe Barthelemy, Khalid Oumzil, Palma Rocchi, Julie Acunzo
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Abstract
The present invention concerns an oligonucleotide modified by substitution at the 3′ or the 5′ end by a moiety comprising at least one ketal functional group, wherein the ketal carbon of said ketal functional group bears two saturated or unsaturated, linear or branched, hydrocarbon chains comprising from 1 to 22 carbon atoms, and the use therefore as a medicament, in particular for use for treating cancer.
Claims26
An oligonucleotide modified by substitution at the 3′ or the 5′ end by a moiety comprising at least one ketal functional group, wherein the ketal carbon of said ketal functional group bears two saturated or unsaturated, linear or branched, hydrocarbon chains comprising from 1 to 22 carbon atoms.
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Dependencies are inferred from the claim text.