Method for Inducing Exocrine Pancreatic Cells
AssigneeKyoto University
InventorsKenji Osafune, Michinori Funato, Norikazu Nishino
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Abstract
An object of the present invention is to provide a method for inducing the differentiation of pancreatic precursor cells into exocrine pancreatic cells. The above object is achieved by providing a method for inducing the differentiation of pancreatic precursor cells into exocrine pancreatic cells using a culture solution containing a histone deacetylase inhibitor and/or a ligand protein for a Notch signal, and a protein kinase C activator.
Claims27
A method for producing exocrine pancreatic cells from PDX1-positive pancreatic precursor cells, comprising a step of
- culturing PDX1-positive pancreatic precursor cells in a culture solution supplemented with a histone deacetylase inhibitor or a ligand protein for a Notch signal, and a protein kinase C activator.
A kit for producing exocrine pancreatic cells from PDX1-positive pancreatic precursor cells, comprising
- a histone deacetylase inhibitor or a ligand protein for a Notch signal, and a protein kinase C activator.
A method for producing exocrine pancreatic cells from PDX1-positive pancreatic precursor cells, comprising a step of
- culturing PDX1-positive pancreatic precursor cells in a culture solution supplemented with a histone deacetylase inhibitor and a ligand protein for a Notch signal, and a protein kinase C activator.
A kit for producing exocrine pancreatic cells from PDX1-positive pancreatic precursor cells, comprising
- a histone deacetylase inhibitor and a ligand protein for a Notch signal, and a protein kinase C activator.
Dependencies are inferred from the claim text.