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US 2016/0108358 A1Published application
Method of assembling a 3d tissue culturing scaffold
AssigneeVivabiocell S.P.A.
InventorFrancesco CURCIO
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Abstract
A continuous device for culturing mammalian cells in a three-dimensional structure for the transplantation or implantation in vivo is described. The culturing device comprises (a) a scaffold formed by a matrix of interconnected growth surfaces spaced at regular intervals and (b) a fluid distribution means at the inlet and the exit of the growth areas. The device is particularly useful for culturing bone cells for dental implants or bone reconstruction.
Claims17
A method of assembling a 3D tissue culturing scaffold comprising:
- defining a 3D matrix of interconnected growth surfaces of a 3D tissue culture scaffold having regular and repetitive 3D structures defining open spaces along x, y, and z Cartesian axes;
- varying parameters associated with the dimensions of the open spaces;
- optimizing flow by computationally analyzing fluid flow distribution throughout the defined scaffold based on the varied parameters to establish optimum open space dimensions;
- and
- producing the tissue culture scaffold according to the optimum open space dimension by assembling 2D layers over each other.
2 more elements
Dependencies are inferred from the claim text.