Polymer/Copper Combination for Targeted Cancer Therapy
AssigneeUniversity of South Carolina
InventorsPeisheng Xu, Huacheng He
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Abstract
Polymer/copper combination that can selectively target and kill cancer cells are described. Materials can include the reaction product of a biocompatible hydrophilic polymer and pyridine-2-thiol containing monomer. The copolymer reaction product can include pyridine-2-thiol side groups pendant to the backbone via a disulfide linkage. The hydrophilic component can form the polymer backbone and/or can form hydrophilic pendant groups off of the backbone. Copper ions can be associated with the copolymer.
Claims19
A polymer/copper combination comprising a biocompatible copolymer, the biocompatible copolymer including pyridine-2-thiol groups pendant to a backbone of the copolymer via a disulfide linkage, the biocompatible copolymer comprising a hydrophilic component, the polymer/copper combination further comprising copper ions
A method for decreasing the viability of cancer cells, the method comprising delivery of a polymer/copper combination to an environment comprising the cancer cells, the polymer/copper combination comprising a biocompatible copolymer, the biocompatible copolymer including pyridine-2-thiol groups pendant to a backbone of the copolymer via a disulfide linkage, the biocompatible copolymer comprising a hydrophilic component, the polymer/copper combination further comprising copper ions.
Dependencies are inferred from the claim text.