Apolipoprotein e polypeptides and their use
AssigneesUniversity of Pittsburgh—Of the Commonwealth System of Higher Education, University of South Carolina
InventorsTianyi Wang, Shufeng Liu, Fan Daping
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Abstract
Disclosed herein are several apoplipoprotein E (ApoE) polypeptides, and nucleic acids encoding these polypeptides, that can be used to treat or prevent a hepatitis infection in a subject, such as a hepatitis C virus infection. These ApoE polypeptides can inhibit the entry of hepatitis C virus into cells, and inhibit viral replication. Nucleic acids encoding these polypeptides are also disclosed, as well as methods
Claims20
A non-naturally occurring isolated polypeptide comprising the amino acid sequence set forth as SEQ ID NO:
- 1, wherein the polypeptide is between 29 and 66 amino acids in length, and wherein the polypeptide can inhibit the entry of a hepatitis C virus into a cell.
A dimer comprising two polypeptides, wherein each of the two polypeptides comprises the amino sequence set forth as SEQ ID NO:
- 1, wherein each of the two polypeptides comprises an N-terminal cysteine, and wherein each of the two polypeptides is at most 32 amino acids in length.
Dependencies are inferred from the claim text.