Interference Peptides and Use Thereof
AssigneeThe University of Western Australia
InventorPilar BLANCAFORT
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Abstract
A purified and isolated peptide comprises an amino acid sequence of SEQ ID NOs: 1 to 8. A method is also provided for preventing interaction, e.g. binding, of EN1 with EPRS in a cell by introducing, into the cell, a peptide having a sequence of SEQ ID NOs: 1 to 8, which results in the peptide interacting with EPRS thereby preventing an interaction of EPRS with EN1. Apoptosis can be induced in a cell expressing either or both of EN1 and EN2, by introducing into the cell, a peptide of SEQ ID NOs: 1 to 8.
Claims20
A purified and isolated peptide comprising an amino acid sequence selected from:
- a. any one of SEQ ID NOs:
- 1 to 4;
- or
- b. the amino acid sequence PL2V3W4PAWV8Y9C10TRSDR,
- wherein:
- L2 is one of:
- L, M, or I;
- V3 is one of:
- V or L;
- W4 is one of:
- W, Y, or W analog;
- V8 is one of:
- V or I;
- Y9 is one of:
- Y or F;
- and
- C10 is one of:
- C or S.
A purified and isolated peptide comprising an amino acid sequence selected from:
- a. an amino acid sequences of SEQ ID NOs:
- 5 to 8;
- or
- b. KKKRKPL2V3W4PAWV8Y9C10TRSDR, wherein:
- L2 is one of:
- L, M, or I;
- V3 is one of:
- V or L;
- W4 is one of:
- W, Y, or W analog;
- V8 is one of:
- V or I;
- Y9 is one of:
- Y or F;
- and
- C10 is one of:
- C or S.
Dependencies are inferred from the claim text.