Vectors encoding rod-derived cone viability factor
AssigneeWellstat Ophthalmics Corporation
InventorTianci LUO
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Abstract
The present invention relates to nucleic acids coding for and capable of expressing a rod-derived cone viability factor (RdCVF) and viral vectors containing these nucleic acids. The invention also relates to compositions and pharmaceutical preparations comprising these nucleic acids or vectors, methods of producing or secreting an RdCVF, and methods of treatment.
Claims27
A polynucleotide comprising a nucleotide sequence encoding a rod-derived cone viability factor (RdCVF) protein operatively linked to a second nucleotide sequence encoding an N-terminal signal sequence,
- wherein the RdCVF coding sequence comprises a recoded nucleotide sequence;
- and
- the N-terminal signal sequence is selected from the group consisting of an Igk signal sequence, a human growth hormone (HGH), a brain derived neurotrophic factor (BDNF), an insulin growth factor 1 (IGF-1), and a β-glucoronidase (GUSB).
The method of claim 39, wherein the viral vector or the polynucleotide is administered by intravitreal injection, injection to the intraanterior chamber of the eye, subconjunctival injection or subtenon injection.
Dependencies are inferred from the claim text.