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US 2016/0108098 A1Published application
Therapeutic peptides
AssigneeGlaxoSmithKline Intellectual Property Development Limited
InventorsSteven Thomas DOCK, Yulin WU, Ved P Srivastava, Robert Neil HUNTER, III, Andrew James CARPENTER
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Abstract
The present invention relates to novel analogs of PYY that have an improved therapeutic profile when compared to native human PYY. These novel PYY analogs are useful in the treatment of obesity, diabetes, and other disorders.
Claims17
1-16. (canceled)
A polypeptide comprising the amino acid sequence:
- (SEQ ID NO:
- 1)
- ProLysProGluXaa1ProGlyXaa2AspAlaSerXaa3GluGluXaa4
- Xaa5Xaa6TyrTyrAlaXaa7LeuArgXaa8TyrXaa9AsnTrpXaa10
- ThrArgGlnArgTyr
- or a salt thereof, wherein:
- Xaa1 is Ala, His, or Ser;
- Xaa2 is Glu or Lys;
- Xaa3 is Pro or Ala;
- Xaa4 is Leu or Trp;
- Xaa5 is Asn, Ala, or Thr;
- Xaa6 is Arg or Lys;
- Xaa7 is Ser, Asp, or Ala;
- Xaa8 is His or Lys;
- Xaa9 is Leu or Ile;
- and
- Xaa10 is Val or Leu.
14 more elements
A polypeptide consisting of the amino acid sequence:
- ProLysProGluXaa1ProGlyXaa2AspAlaSerXaa3GluGlu Xaa4Xaa5 Xaa6TyrTyrAlaXaa7LeuArg Xaa8Tyr Xaa9 AsnTrp Xaa10ThrArgGlnArgTyr-NH2 (SEQ ID NO:2) or a salt thereof, wherein:
- Xaa1 is Ala, His, or Ser;
- Xaa2 is Glu or Lys;
- Xaa3 is Pro or Ala;
- Xaa4 is Leu or Trp;
- Xaa5 is Asn, Ala, or Thr;
- Xaa6 is Arg or Lys;
- Xaa7 is Ser, Asp, or Ala;
- Xaa8 is His or Lys;
- Xaa9 is Leu or Ile;
- and
- Xaa10 is Val or Leu.
9 more elements
Dependencies are inferred from the claim text.