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US 2016/0108095 A1Published application
Polypeptides
AssigneeAffibody AB
InventorsCaroline Ekblad, Lars Abrahmsen
Life of this patent
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Abstract
The present disclosure relates to a class of engineered polypeptides having a binding affinity for albumin. It also relates to new methods and uses that exploit binding by these and other compounds to albumin in different contexts, some of which have significance for treatment or diagnosis of disease in mammals including humans.
Claims62
An albumin binding polypeptide comprising an amino acid sequence selected from:
- i)
- (SEQ ID NO:
- 204)
- LAX3AKX6X7ANX10 ELDX14YGVSDF YKRLIX26
- KAKTVEGVEALKX39X40ILX43X44LP
- wherein independently of each other
- X3 is selected from E, S, Q and C;
- X6 is selected from E, S and C;
- X7 is selected from A and S;
- X10 is selected from A, S and R;
- X14 is selected from A, S, C and K;
- X26 is selected from D and E;
- X39 is selected from D and E;
- X40 is selected from A and E;
- X43 is selected from A and K;
- X44 is selected from A, S and E;
- L in position 45 is present or absent;
- and
- P in position 46 is present or absent;
- and
- ii) an amino acid sequence which has at least 95% identity to the sequence defined in i).
18 more elements
-84. (canceled)
Dependencies are inferred from the claim text.