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US 2016/0108092 A1Published application
Selectin Inhibitors, Composition, and Uses Related Thereto
AssigneesEmory University, Beth Israel Deaconess Medical Center, Inc.
InventorsRichard D. CUMMINGS, Elliot L. CHAIKOF, Venkata R. NAMURTHY, Mohammed SARDAR
Life of this patent
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Abstract
This disclosure relates to selectin inhibitors, compositions, and methods related thereto. In certain embodiments, the disclosure relates to glycopeptides that contain one more modified amino acids conjugated to a saccharide or polysaccharide. In certain embodiments, the disclosure relates to uses of the glycopeptides as anti-inflammatory, anti-thrombotic, or anti-metastatic agents.
Claims22
An isolated glycopeptide comprising Y1X1Y2X2X3Y3X4X5X6Z1X7W1 (SEQ ID NO:
- 1) or salts thereof, wherein
- W1 is threonine or serine substituted with a saccharide or polysaccharide
- X1, X2, X3, X4, X5, X6, and X7 individually and independently any amino acid,
- Y1, Y2, and Y3 are each individually and independently tyrosine, phenylalanine, or phenylglycine unsubstituted or substituted with —SO3H, —CH2SO3H, —CF2SO3H, —CO2H, —CONH2, —NHSO2CH3, —SO2NH2, or —CH2PO3H, and
- Z1 is proline or hydroxyproline.
2 more elements
(canceled)
(canceled)
Dependencies are inferred from the claim text.