Therapeutics for the induction of endogenous steroidogenesis and methods associated with their identification
AssigneeThe Royal Institution for the Advancement of Learning/Mcgill University
InventorsVassilios Papadopoulos, Yasaman Aghazadeh, Jinjiang Fan
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Abstract
The present disclosure provides agents capable of promoting endogenous steroid production (such as endogenous testosterone production) without altering the endogenous luteinizing hormone. The present disclosure also provides associated therapeutic methods as well as screening assays for identifying further therapeutic agents for the prevention, treatment and/or alleviations of symptoms associated with hypogonadism.
Claims25
An isolated peptide having the amino acid sequence RVTQSNF (SEQ ID NO:
- 5).
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A method for determining the usefulness of an agent for promoting endogenous steroid production in a cell, said method comprising:
- combining the agent, a 14-3-3ε protein and a VDAC1 protein;
- determining if the agent promotes or impedes the formation and/or stability of a complex between the 14-3-3ε protein and the VDAC1 protein;
- and
- characterizing the agent (i) as being useful for promoting endogenous steroid production if the agent impedes the formation and/or stability of the complex or (ii) as lacking utility to promote endogenous steroid production if the agent promotes the formation and/or stability of the complex.
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Dependencies are inferred from the claim text.