Preparation and Uses of Obeticholic Acid
AssigneeIntercept Pharmaceuticals, Inc.
InventorsAndré Steiner, Heidi Waenerlund Poulsen, Emilie Jolibois, Melissa Rewolinski, Ralf Gross, Emma Sharp, Fiona Dubas-Fisher, Alex Eberlin
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Abstract
The present invention relates to obeticholic acid: or a pharmaceutically acceptable salt, solvate or amino acid conjugate thereof. Obeticholic acid is useful for the treatment or prevention of a FXR mediated disease or condition, cardiovascular disease or cholestatic liver disease, and for reducing HDL cholesterol, for lowering triglycerides in a mammal, or for inhibition of fibrosis. The present invention also relates to processes for the synthesis of obeticholic acid.
Claims22
A crystalline form of obeticholic acid characterized by an X-ray powder diffraction pattern comprising peaks at about 5.0 and 5.3 degrees 2-theta.
A crystalline form of obeticholic acid, wherein the crystalline form is selected from the group consisting of D, F, G, and I.
The crystalline form of claim 21 wherein the crystalline form is characterized by an X-ray diffraction pattern substantially similar to that set forth in FIG. 57.
Dependencies are inferred from the claim text.