Imidazotriazinecarbonitriles useful as kinase inhibitors

A compound according to Formula (I):

• or a pharmaceutically acceptable salt thereof, wherein
• R1 is selected from the group consisting of H, F, Cl, Br, CN, and C1-6alkyl;
• R2 is selected from the group consisting of aryl substituted with 1-5 R6 and heteroaryl substituted with 1-5 R6;
• R3 is selected from the group consisting of hydrogen and C1-6alkyl substituted with 1-5 Re;
• optionally R2 and R3 together with the nitrogen atom to which they are attached form a heterocyclic ring substituted with 1-5 R6;
• R4 is selected from the group consisting of H, C1-6alkyl substituted with 1-5 Re, —(CH2)rORb, —(CH2)rS(O)pRc, —(CH2)rC(═O)Rd, —(CH2)rNRaRa, —(CH2)rC(═O)NRaRa, —(CH2)rNRaC(═O)Rd, —(CH2)rNRaC(═O)ORb, —(CH2)rOC(═O)NRaRa, —(CH2)rNRaC(═O)NRaRa, —(CH2)rC(═O)ORb, —(CH2)rS(O)2NRaRa, —(CH2)rNRaS(O)2NRaRa, —(CH2)rNRaS(O)2Rc, —(CH2)r—C3-10 carbocyclyl substituted with 1-5 Re, —(CH2)r-heterocyclyl substituted with 1-5 Re;
• R5 is selected from the group consisting of H and C1-6alkyl substituted with 1-5 Re;
• R6, at each occurrence, is independently selected from the group consisting of H, F, Cl, Br, CN, —(CRgRg)rNR7R7, NO2, —ORb, —C(═O)NR7R7, —C(═O)Rb, —NRaC(═O)ORb, —NRaC(═O)(CRgRg)rNRaRa, C1-6 alkyl substituted with 1-5 Re, C2-4 alkenyl substituted with 1-5 Re, —(CRgRg)rC3-6carbocyclyl substituted with 1-5 R8, and —(CRgRg)rheterocyclyl substituted with 1-5 R8;
• or two adjacent R6 groups are taken together with the ring atoms to which they are attached to form a fused heterocyclyl or carbocyclyl, each substituted with 1-5 R8;
• R7, at each occurrence, is independently selected from the group consisting of H, C1-6 alkyl substituted with 1-5 Re, —(CH2)r—C3-10carbocyclyl substituted with 1-5 R8, and —(CH2)r-heterocyclyl substituted with 1-5 R8;
• or R7 and R7 together with the nitrogen atom to which they are both attached form a heterocyclic ring substituted with 1-5 R8;
• R8, at each occurrence, is independently selected from the group consisting of H, F, Cl, Br, C1-6 alkyl substituted with 1-5 Re, C2-6 alkenyl substituted with 1-5 Re, C2-6 alkynyl substituted with 1-5 Re, ═O, —(CRgRg)rORb, —(CRgRg)rS(O)pRc, —(CRgRg)rC(═O)(CRgRg)rRd, —(CRgRg)rNRaRa, —(CRgRg)rC(═O)NRaRa, —(CRgRg)rC(═O)NRaS(O)pRc, —(CRgRg)rNRa(CRgRg)rC(═O)Rd, —(CRgRg)rNRaC(═O)ORb, —(CRgRg)rOC(═O)(CRgRg)rRd, —(CRgRg)rOC(═O)(CRgRg)rC(═O)Rd, —(CRgRg)rOC(═O)(CRgRg)rC(═O)NRaRa, —(CRgRg)rOC(═O)(CRgRg)rNRaC(═O) Rb, —(CRgRg)rOC(═O)(CRgRg)rNRaRa, —(CRgRg)rNRa(CRgRg)rC(═O)NRaRa, —(CRgRg)rC(═O)(CH2)rORb, —(CRgRg)rC(═O)(CRgRg)rOC(═O)Rb —(CRgRg)rS(O)pNRaRa, —(CRgRg)rNRaS(O)pNRaRa, —(CRgRg)rNRaS(O)pRc, —OPO3H2, —(CRgRg)rNRaC(═O)O(CRgRg)rO(CRgRg)rO(CRgRg)rO(CRgRg)rO(CRgRg)rO(CRgRg)rOC1-4alkyl, —(CRgRg)r—C3-10carbocyclyl substituted with 1-5 Re and —(CRgRg)r-heterocyclyl substituted with 1-5 Re;
• Ra, at each occurrence, is independently selected from the group consisting of H, CN, C1-6 alkyl substituted with 1-5 Re, C2-6 alkenyl substituted with 1-5 Re, C2-6 alkynyl substituted with 1-5 Re, —(CH2)r—C3-10carbocyclyl substituted with 1-5 Re, and —(CH2)r-heterocyclyl substituted with 1-5 Re;
• or Ra and Ra together with the nitrogen atom to which they are both attached form a heterocyclic ring substituted with 1-5 Re;
• Rb, at each occurrence, is independently selected from the group consisting of H, C1-6 alkyl substituted with 1-5 Re, C2-6 alkenyl substituted with 1-5 Re, C2-6 alkynyl substituted with 1-5 Re, —(CH2)r—C3-10carbocyclyl substituted with 1-5 Re, and —(CH2)r-heterocyclyl substituted with 1-5 Re;
• Rc, at each occurrence, is independently selected from the group consisting of C1-6 alkyl substituted with 1-5 Re, C2-6alkenyl substituted with 1-5 Re, C2-6alkynyl substituted with 1-5 Re, C3-6carbocyclyl, and heterocyclyl;
• Rd, at each occurrence, is independently selected from the group consisting of H, OH, C1-6 alkyl substituted with 1-5 Re, C2-6alkenyl substituted with 1-5 Re, C2-6alkynyl substituted with 1-5 Re, —(CH2)r—C3-10carbocyclyl substituted with 1-5 Re, and —(CH2)r-heterocyclyl substituted with 1-5 Re;
• Re, at each occurrence, is independently selected from the group consisting of H, N3, C1-6alkyl substituted with 1-5 Rf, C2-6alkenyl, C2-6alkynyl, —(CH2)r—C3-6 cycloalkyl, —(CH2)r-heterocyclyl, F, Cl, Br, —(CH2)rCN, NO2, ═O, —OPO3H2, —OSi(C1-4alkyl)3, —(CH2)rOC1-5 alkyl, —(CH2)rO(CH2)rOC1-5 alkyl, —(CH2)rOH, —(CH2)rS(O)2C1-5alkyl, —(CH2)rS(O)2Rf, —(CH2)rNHS(O)2C1-5alkyl, —S(O)2NH2, SH, —(CH2)rNRfRf, —(CH2)rNHC(═O)ORf, —(CH2)rNHC(═O)Rf, —(CH2)rNHC(═NH)NRfRf, —(CH2)rC(═O)(CH2)rRf, and —(CH2)rC(═O)ORf;
• Rf, at each occurrence, is independently selected from the group consisting of H, —(CH2)rOH, —(CH2)rOC1-5alkyl, C1-5alkyl (optionally substituted with F, Cl, OH, NH2), C3-6 cycloalkyl optionally substituted with NH2, —(CH2)rS(O)pC1-4alkyl, —NHC(═O)C1-4alkyl, —C(═O)NH2, —C(═O)OC1-4alkyl, —C(═O)C1-4alkyl, —(CH2)rphenyl, —(CH2)rheterocyclyl optionally substituted with alkyl and CN, or Rf and Rf together with the nitrogen atom to which they are both attached form a heterocyclic ring optionally substituted with C1-4alkyl;
• Rg, at each occurrence, is independently selected from the group consisting of H, F, OH, and C1-5alkyl;
• p, at each occurrence, is independently selected from the group consisting of zero, 1, and 2;
• and
• r, at each occurrence, is independently selected from the group consisting of zero, 1, 2, 3, 4, and 5.