Novel Phthalazinone-Pyrrolopyrimidinecarboxamide Derivatives

A compound of formula (1)

• wherein
• R1 represents a phenyl derivative of formulae (a) or (b)
• wherein
• R2 is 1-4C-alkoxy or 1-4C-alkoxy predominantly or completely substituted by fluorine,
• R3 is 1-4C-alkoxy, 3-5C-cycloalkoxy, 3-5C-cycloalkoxymethoxy or 1-4C-alkoxy predominantly or completely substituted by fluorine,
• R4 is 1-4C-alkoxy or 1-4C-alkoxy predominantly or completely substituted by fluorine,
• R5 is 1-4C-alkyl,
• R6 is hydrogen or 1-4C-alkyl,
• or wherein R5 and R6 together and with inclusion of the two carbon atoms, to which they are bonded, form a spiro-linked 5-, 6- or 7-membered hydrocarbon ring, optionally interrupted by an oxygen or sulphur atom,
• R7 is hydrogen,
• R8 is 1-4C alkyl,
• or R7 and R8 together form a 3C- to 5C-alkylene group,
• R9 is hydrogen or 1-4C alkyl,
• or wherein R8 and R9 together and with inclusion of the carbon atom, to which they are bonded, form a spiro-linked 5-, 6- or 7-membered hydrocarbon ring,
• m is 1 or 2,
• R10 is independently from each other hydrogen, 5-7C-cycloalkyl, 1-6C-alkyl, —CH(CH3)—R11 or —CH2—R12,
• wherein
• R11 is unsubstituted phenyl or hydroxyl,
• R12 is hydroxyl, 5-7C-cycloalkyl, —N-(1-2C-alkyl)2, —CH2—S-(1-2C-alkyl), benzyl, unsubstituted phenyl, phenyl substituted by R13, or phenyl substituted by R13 and R14,
• wherein
• R13 is halogen, 1-4C alkoxy, 1-6C alkyl, 1-4C fluoroalkyl, hydroxyl, phenyl, —C(O)NH2, —CN, 2-oxoazetidin-1-yl or 2-oxopyrrolidin-1-yl,
• R14 is halogen, 1-4C alkoxy, 1-6C alkyl, 1-4C fluoroalkyl, hydroxyl, phenyl, —C(O)NH2 or —CN,
• or R12 is selected from imidazol-2-yl, imidazol-4-yl, pyrazol-1-yl, thiophen-2-yl, thiophen-3-yl, thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, indol-2-yl, indol-3-yl, 1-methyl-indol-2-yl or 1-methyl-indol-3-yl, or
• R12 is —CH2—C(O)—R15,
• wherein
• R15 is hydroxyl, —N(R16)2, piperidin-1-yl, pyrrolidin-1-yl or benzyloxy, wherein
• R16 is independently from each other hydrogen or 1-4C-alkyl,
• R17 is hydrogen or methyl,
• R18 is —CH2-3-6C-cycloalkyl,
• R19 is halogen, hydroxyl, 1-4C alkoxy, 1-4C alkoxy predominantly or completely substituted by fluorine or 1-4C-fluoroalkyl,
• R20 is halogen, hydroxyl, 1-4C alkoxy or 1-4C alkoxy predominantly or completely substituted by fluorine,
• or R19 and R20 together form a 1-2C alkylenedioxy group,
• or a stereoisomer of the compound or a salt of the compound or a salt of the stereoisomer of the compound.