Imidazole derivatives and methods of use thereof for improving the pharmacokinetics of a drug

A compound having the formula (I):

• or a pharmaceutically acceptable salt thereof,
• wherein:
• A is:
• B is phenyl or 5 or 6-membered monocyclic heteroaryl, which is optionally substituted with up to three R1 groups, which can be the same or different;
• X is O, —N(R6)— or —C(R5)2—;
• Y is —C(O)—, —S(O)2— or —CH2—;
• n is 0, 1 or 2;
• R1 is selected from C1-C6 alkyl, C6-C10 aryl, 5 or 6-membered heteroaryl, 4 to 7-membered monocyclic heterocycloalkyl and C3-C6 cycloalkyl, wherein said C6-C10 aryl group, said 5 or 6-membered heteroaryl group, said 4 to 7-membered monocyclic heterocycloalkyl group or said C3-C6 cycloalkyl group can be optionally substituted with up to four R7 groups, which can be the same or different, and wherein said C3-C6 cycloalkyl group can be fused to a benzene ring and said fused benzene ring can be optionally substituted with up to four R7 groups, which can be the same or different;
• each occurrence of R2 is independently selected from H, C1-C6 alkyl and C3-C6 cycloalkyl, or both R2 groups, together with the common carbon atom to which they are each attached, join to form a C3-C7 cycloalkyl group;
• each occurrence of R3 is independently selected from H, —OH, halo, C1-C6 alkyl, —O—C1-C6 alkyl, —(C1-C3 alkylene)n-(C3-C6 cycloalkyl) and —(C1-C3 alkylene)n-(5 or 6-membered monocyclic heterocycloalkyl), wherein said C3-C6 cycloalkyl group and said 5 or 6-membered monocyclic heterocycloalkyl group can be optionally substituted on one or more ring carbon atoms with up to 3 groups, each independently selected from H, —OH, halo, C1-C6 alkyl, C1-C6 haloalkyl, —O—C1-C6 alkyl and C3-C6 cycloalkyl;
• or an R3 group and an R5 group, together with the carbon atoms to which they are attached, can combine to form a C3-C6 cycloalkyl group, a 5 or 6 membered monocyclic heterocycloalkyl group or a 5 or 6 membered heteroaryl group, wherein said C3-C6 cycloalkyl group, said 5 or 6 membered monocyclic heterocycloalkyl group and said 5 or 6 membered heteroaryl group can be optionally substituted on one or more ring carbon atoms with up to 3 groups, each independently selected from H, —OH, halo, C1-C6 alkyl, C1-C6 haloalkyl, —O—C1-C6 alkyl and C3-C6 cycloalkyl;
• or an R3 group and an R6 group, together with the carbon atoms to which they are attached, can combine to form a 5 or 6 membered monocyclic heterocycloalkyl group or a 5 or 6 membered heteroaryl group, wherein said 5 or 6 membered monocyclic heterocycloalkyl group and said 5 or 6 membered heteroaryl group can be optionally substituted on one or more ring carbon atoms with up to 3 groups, each independently selected from H, —OH, halo, C1-C6 alkyl, C1-C6 haloalkyl, —O—C1-C6 alkyl and C3-C6 cycloalkyl;
• each occurrence of R4 is independently selected from H, —OH, halo, C1-C6 alkyl, —O—C1-C6 alkyl, —(C1-C3 alkylene)n-(C3-C6 cycloalkyl) and —(C1-C3 alkylene)n-(5 or 6-membered monocyclic heterocycloalkyl), wherein said C3-C6 cycloalkyl group and said 5 or 6-membered monocyclic heterocycloalkyl group can be optionally substituted on one or more ring carbon atoms with up to 3 groups, each independently selected from H, —OH, halo, C1-C6 alkyl, C1-C6 haloalkyl, —O—C1-C6 alkyl and C3-C6 cycloalkyl;
• or an R4 group and an R5 group, together with the carbon atoms to which they are attached, can combine to form a C3-C6 cycloalkyl group, a 5 or 6 membered monocyclic heterocycloalkyl group or a 5 or 6 membered heteroaryl group, wherein said C3-C6 cycloalkyl group, said 5 or 6 membered monocyclic heterocycloalkyl group and said 5 or 6 membered heteroaryl group can be optionally substituted on one or more ring carbon atoms with up to 3 groups, each independently selected from H, —OH, halo, C1-C6 alkyl, C1-C6 haloalkyl, —O—C1-C6 alkyl and C3-C6 cycloalkyl;
• or an R4 group and an R6 group, together with the carbon atoms to which they are attached, can combine to form a 5 or 6 membered monocyclic heterocycloalkyl group or a 5 or 6 membered heteroaryl group, wherein said 5 or 6 membered monocyclic heterocycloalkyl group and said 5 or 6 membered heteroaryl group can be optionally substituted on one or more ring carbon atoms with up to 3 groups, each independently selected from H, —OH, halo, C1-C6 alkyl, C1-C6 haloalkyl, —O—C1-C6 alkyl and C3-C6 cycloalkyl;
• each occurrence of R5 is independently H, —NH(R6), —OH, halo, C1-C6 alkyl, —O—C1-C6 alkyl, —(C1-C3 alkylene)n-(C3-C6 cycloalkyl), —(C1-C3 alkylene)n-(5 to 7-membered monocyclic heterocycloalkyl) and —(C1-C3 alkylene)n-(9 or 10-membered bicyclic heterocycloalkyl) wherein said C3-C6 cycloalkyl group, said 5 to 7-membered monocyclic heterocycloalkyl group and said 9 or 10-membered bicyclic heterocycloalkyl group can be optionally substituted on one or more ring carbon atoms with up to 3 groups, each independently selected from R7, or both R5 groups, and the common carbon atom to which they are each attached, join to form a spirocyclic C3-C6 cycloalkyl group or a spirocyclic 5 to 7-membered monocyclic heterocycloalkyl group, wherein said spirocyclic C3-C6 cycloalkyl group and said spirocyclic 5 or 6-membered monocyclic heterocycloalkyl group can be optionally and independently substituted on up to 3 ring carbon atoms with a group selected from H, —OH, halo, C1-C6 alkyl, C1-C6 haloalkyl, —O—C1-C6 alkyl and C3-C6 cycloalkyl;
• each occurrence of R6 is independently selected from H, C1-C6 alkyl, C3-C7 cycloalkyl, —(C1-C6 alkyl)-O—(C1-C6 alkyl), 4 to 7-membered monocyclic heterocycloalkyl, —C(O)—(C1-C6 alkyl) and —S(O)2—(C1-C6 alkyl);
• each occurrence of R7 is independently selected from C1-C6 alkyl, C6-C10 aryl, 5 or 6-membered heterocycloalkyl, 5 or 6-membered heteroaryl, C1-C6 hydroxyalkyl, C1-C6 haloalkyl, halo, —CN, —N(R6)2, —CH2N(R8)2, —OR6, —C(O)OR6, —SR6, —S(O)2R6 and —C(O)N(R6)2, wherein said C6-C10 aryl group, said 5 or 6-membered heteroaryl group or said 5 or 6-membered heterocycloalkyl group can be optionally substituted with a group selected from C1-C6 alkyl, halo, C1-C6 hydroxyalkyl, C1-C6 haloalkyl, halo, —CN, —N(R6)2, —OR6 and —(C1-C6 alkylene)-OR6.